Weighted search was explored significantly in recent years for path-finding problems, but until now was barely considered for optimization tasks such as MPE/MAP and Weighted CSPs. An important virtue of weighted search schemes, especially in the context of anytime search, is that they are w-optimal, i.e. when terminated, they return a weight w, and a solution cost C, such that C ≤ w·C* , where C* is the optimal cost. In this paper we introduce Weighted Branch and Bound (WBB) for graphical models and provide a broad empirical evaluation of its performance compared with one of the best unweighted anytime search scheme, BRAOBB (won Pascal 2011 competition). We also compare against weighted best-first (WBF). Our results show that W BB can be superior to both un-weighted BB and to weighted BF on a significant number of instances. We also illustrate the benefit of weighted search in providing suboptimality relative error bounds.