|
Zhaoxia Yu, Ph.D.
zhaoxia ics.uci.edu |
Research
Interests
Statistical methods and
applications.
Lecture
materials for intro to mixed-effects models (Feb 2023)
Slides for intro-to-stat talk for a UCI
research club (Jan 2022)
Lecture materials for CNCM
2023 (Aug 2023): web,
zip
Current
Teaching
I will be teaching
Statistics 200A in Fall 2024.
Courses that I taught
before: STAT8, STAT120A/B/C, STAT140/240, STAT257, STAT262, STAT200A/B/C, STAT200AP,
STAT240P
Google
Scholar: https://scholar.google.com/citations?user=Byf84YsAAAAJ&hl=en
Some
Recent Work
o
Du M, Johnston K, Berrocal
V, Li W, Xu X, Yu Z. (2024) ULV: A robust statistical method for
clustered data, with applications to multi-subject, single-cell omics data. Submitted. https://github.com/yu-zhaoxia/ULV
o
X Qiao, SF Grieco, Z Yu, TC Holmes, X Xu. (2024) Intranasal
Delivery of Ketamine Induces Cortical Disinhibition. eneuro
11 (1)
o
S Molloi, AR Polivka, Y Zhao, J Redmond, M Itkin,
I Antunes, Z Yu. (2023) Dynamic contrast-enhanced CT lymphangiography to
quantify thoracic duct lymphatic flow. Radiology 309 (3), e230959
o
D'Angelo L, Canale
A, Yu Z, Guindani M. (2023) Bayesian
nonparametric analysis for the detection of spikes in noisy calcium imaging
data. Biometrics. 79 (2), 1370-1382.
o
Au DD, Foden AJ, Park SJ, Nguyen TH, Liu JC,
Tran MD, Olga G. Jaime, Yu Z, and Holmes TC. (2022) Mosquito
Cryptochromes expressed in Drosophila confer species-specific behavioral light
responses. Current Biology. In print.
o
Feng J, Zhang L, Chen C, Sheng J, Ye Z, Feng
K, Liu J, Cai Y, Zhu B, Yu Z, Chen C, Dong Q, Xue
G. (2022) A cognitive neurogenetic approach to uncovering the structure of
executive functions. Nature Communications. In print.
o
Wu K, Chen C, Yu Z. (2022) Handsome or
Rugged? A Speed-dating Study of Ovulatory Shifts in Womens
Preferences for Masculinity in Men. Under revision for Human Nature.
o
Gauran I, Xue G, Chen C, Ombao H, Yu Z.
(2022) Ridge Penalization in High-Dimensional Testing with applications to
Imaging Genetics. Frontiers in Neuroscience 16:836100.
o
Yu Z, Guindani M, Grieco SF, Chen L, Holmes TC, Xu X. (2022) Beyond t-Test
and ANOVA: applications of mixed-effects models for more rigorous statistical
analysis in neuroscience research. Neuron. 110: 21-23.
Data
and web-based supplemental materials are available from
https://yu-zhaoxia.github.io/MM_in_Neuroscience/
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Shen T, Lur G, Xu X,
Yu Z. (2022) To Deconvolve, or Not to Deconvolve: Inferences of Neuronal
Activities using Calcium Imaging Data. Journal Neuroscience Methods. 366: 109431
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Shen, Johnston K, Lur
G, Guidani M, Ombao H, Xu
X, Yu Z. (2021) Time-varying ℓ0 optimization for Spike Inference
from Multi-Trial Calcium Recordings. Submitted. arXiv preprint. arXiv:2103.03818
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Pluta D,
Xu X, Gillen D, Yu Z. (2021). A Measurement of
In-Betweenness and Inference Based on Shape Theories. Submitted. arXiv preprint. arXiv:2103.09718
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Brandt AU, Sy M, Bellmann-Strobl
J, Newton BL, Pawling J, Zimmermann HG, Yu Z, Chien
C, Dorr J, Wuerfel JT, Dennis JW, Paul F, Demetriou M
(2021) Association of a Marker of N-Acetylglucosamine With Progressive Multiple
Sclerosis and Neurodegeneration. JAMA Neurology. 78:842-852.
o
Pluta D,
Shen T, Xue G, Chen C, Ombao
H, Yu Z. (2021) Ridge-penalized adaptive Mantel test and its application
in imaging genetics. Statistics in Medicine. 40:5313-5332.
o
Grieco SF,
Qiao X, Zheng X, Liu Y, Chen L, Zhang H, Yu, Z,
Gavornik JP, Lai C, Gandhi SP, Holmes TC. (2020).
Subanesthetic ketamine reactivates adult cortical plasticity to restore vision
from amblyopia. Current Biology, 30:3591-3603.
o
Feng J, Chen C, Cai Y, Ye Z, Feng K, Liu J,
Zhang L, Yang Q, Li A, Sheng J, Zhu B, Yu Z, Chen C, Dong Q, Xue G. (2020) Partitioning heritability analyses unveil the
genetic architecture of human brain multidimensional functional connectivity
patterns. Human Brain Mapping. 41:3305-3317.
o
Sy M, Brandt AU, Lee SU, Newton BL, Pawling J,
Golzar A, Rahman AM, Yu Z, Cooper G, Scheel M,
Paul, F. (2020). N-acetylglucosamine drives myelination by triggering
oligodendrocyte precursor cell differentiation. Journal of Biological
Chemistry, 295:17413-17424.
Older
Articles (selected)
o
Pluta D, Yu
Z, Shen T, Chen C, Xue G, Ombao
H. (2018) Statistical Methods and Challenges in Connectome Genetics. Statistics and Probability Letters.
136:83-86
o
Interiano M, Kazemi K, Wang L, Yang J, Yu Z, Komarova NL. (2018) Musical trends
and predictability of success in contemporary songs on and off the top charts.
To appear in Royal Society Open Science,
5: 171274.
o
Wu K, Chen C, Moyzis RK,
Nuno M, Yu Z, Greenberger E. (2018)
More than Skin Deep: Uncovering Major Histocompatibility Complex (MHC)-Based
Attraction among Asian American Speed-daters. Evolution and Human Behavior, 39(4):447-456.
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Wu K, Chen C, Moyzis RK,
Greenberger E, Yu Z. (2016) Gender
Interacts with Opioid Receptor Polymorphism A118G and Serotonin Receptor
Polymorphism -1438A/G on Speed-dating Success. Human Nature, 27(3):244-60.
o
Yu Z, Demetriou M,
Gillen D. (2015) Genome-wide analysis of gene-gene and gene-environment
interactions using closed-form Wald tests. Genetic
Epidemiology, 39: 446-455.
(software: GG_Wald)
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Yu Z, Li CF, Mkhikian H, Zhou RW, Newton BL, Demetriou M. (2014) Family
studies of Type 1 diabetes reveal additive and epistatic effects between MGAT1
and three other polymorphisms. Genes and
Immunity, 15:218-223.
o
Yu Z, Gillen D, Li
CF, Demetriou M. (2013) Incorporating parental information into family-based
association tests. Biostatistics,
14: 556-572.supplementary material
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Yu Z (2012).
Family-based association tests using genotype data with uncertainty. Biostatistics, 13:228-240.
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Shahbaba B, Shachaf CM, Yu Z. (2012) A pathway analysis method for
genome-wide association studies. Statistics
in Medicine, 31:988-1000.
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Yu Z, Deng L.
(2011) Pseudosibship methods in the case-parents
design. Statistics in Medicine,
30:3236-3251.
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Yu Z, Wang S
(2011). Contrasting linkage-disequilibrium as a multi-locus family-based
association test. Genetic Epidemiology,
35:487-498.
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Yu Z (2011).
Testing gene-gene interactions in the case-parents design. Human Heredity, 71:171-179.
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Weng L, Macciardi F, Subramanian A, Guffanti
G, Potkin SG, Yu
Z, Xie X. (2011) SNP-based pathway enrichment
analysis for genome-wide association studies. BMC Bioinformatics, 12:99.
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Browning B, Yu Z. (2009). Simultaneous genotype
calling and haplotype phasing improves genotype accuracy and reduces false
positive associations for genome-wide association studies. American Journal of Human Genetics, 85:847-861.
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Yu Z, Garner C, Ziogas A, Anton-Culver H, Schaid
D. (2009). Genotype determination for polymorphisms in linkage disequilibrium. BMC Bioinformatics, 10:63.
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Yu Z, Wang L,
Hildebrandt MAT, Schaid D. (2008). Testing whether
genetic variation explains correlation of quantitative measures of gene
expression, and application to genetic network analysis. Statistics in Medicine, 27:3847 - 3867.
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Yu Z, Schaid D. (2007). Methods to impute missing genotypes for
population data. Human Genetics,
122:495-504.
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Yu Z, Schaid D. (2007). Sequential haplotype scan methods for
association analysis. Genetic
Epidemiology, 31: 553-564.
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Levine R, Yu Z, Hanley W, Nitao
J. (2005). Implementing componentwise Hastings
algorithms, Computational Statistics & Data Analysis, 48: 363-389.
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Levine R, Yu Z, Hanley W, Nitao
J. (2005). Implementing the random scan Gibbs sampler, Computational
Statistics, 20: 177-196
(taken in November 2018)